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The effect of partial portacaval transposition on the canine liver

Marchioro, TL and Porter, KA and Brown, BI and Otte, JB and Starzl, TE (1967) The effect of partial portacaval transposition on the canine liver. Surgery, 61 (5). 723 - 732. ISSN 0039-6060

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The influence of nonhepatic splanchnic venous blood on dog liver morphology and biochemical content was investigated by performing partial portacaval transposition, anastomosing the supra-adrenal inferior vena cava to either the right or left branch of the main portal vein. In the resulting preparation, nonhepatic splanchnic venous blood supplies one portion of the liver and systemic venous blood perfuses the remaining fraction,. Seven dogs were studied for 70 to 94 days, 3 with right and 4 with left transposition. No clinical abnormalities were noted. Transient enzyme elevations were seen early after operation but reverted to normal. The most striking feature was the gross and microscopic atrophy and deglycogenation which occurred in the part of the liver receiving systemic venous blood. Blood flow studies were performed in 8 additional dogs with an electromagnetic square wave flowmeter. Flow was measured in both right and left portal vein branches before and 1 to 4 hours after partial transposition to either the right (4 dogs) or left (4 dogs) main branch. Flow rates were increased in 11 instances and remained essentially the same in 5. In 2 more dogs, a jugular venous autograft was placed between the abdominal aorta and the right or left main portal vein branch. Atrophy and deglycogenation in the portion receiving arterial blood was comparable to that described above in liver fractions perfused with systemic venous blood. The evidence from these and earlier experiments that splanchnic venous blood contains a hepatotrophic substance is discussed. © 1967.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Marchioro, TL
Porter, KA
Brown, BI
Otte, JB
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 May 1967
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 61
Number: 5
Page Range: 723 - 732
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062123512, Starzl CV No. 126
Date Deposited: 08 Apr 2010 17:01
Last Modified: 02 Feb 2019 13:56


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