Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production

Kashiwagi, N and Groth, CG and Amend, JR and Gecelter, L and Blanchard, H and Starzl, TE (1969) Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production. Surgery, 65 (3). 477 - 484. ISSN 0039-6060

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Antilymphocyte gamma-G globulin (ALGG) was produced from the serum of immunized horses. Modifications of the preliminary absorption techniques permitted the removal of undesirable, extraneous antibodies. With the use of a batch technique, pure gamma-G globulin could then be removed in bulk quantities. The resulting product was first confirmed to have immunosuppressive qualities in dogs and then given a clinical trial. In patients, its administration occasionally caused low-grade fever and thrombocytopenia. Pain at the injection site was not eliminated. Precipitin antibody responses have apparently been prevented in the patients but not a host response to Forssman antigens. © 1969.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kashiwagi, N
Groth, CG
Amend, JR
Gecelter, L
Blanchard, H
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 March 1969
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 65
Number: 3
Page Range: 477 - 484
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062124346, Starzl CV No. 169
Date Deposited: 08 Apr 2010 17:02
Last Modified: 05 Dec 2017 17:01
URI: http://d-scholarship.pitt.edu/id/eprint/3555

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item