Kashiwagi, N and Groth, CG and Amend, JR and Gecelter, L and Blanchard, H and Starzl, TE
(1969)
Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production.
Surgery, 65 (3).
477 - 484.
ISSN 0039-6060
Abstract
Antilymphocyte gamma-G globulin (ALGG) was produced from the serum of immunized horses. Modifications of the preliminary absorption techniques permitted the removal of undesirable, extraneous antibodies. With the use of a batch technique, pure gamma-G globulin could then be removed in bulk quantities. The resulting product was first confirmed to have immunosuppressive qualities in dogs and then given a clinical trial. In patients, its administration occasionally caused low-grade fever and thrombocytopenia. Pain at the injection site was not eliminated. Precipitin antibody responses have apparently been prevented in the patients but not a host response to Forssman antigens. © 1969.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Kashiwagi, N | | | | Groth, CG | | | | Amend, JR | | | | Gecelter, L | | | | Blanchard, H | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 March 1969 |
Date Type: |
Publication |
Journal or Publication Title: |
Surgery |
Volume: |
65 |
Number: |
3 |
Page Range: |
477 - 484 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0039-6060 |
Other ID: |
uls-drl:31735062124346, Starzl CV No. 169 |
Date Deposited: |
08 Apr 2010 17:02 |
Last Modified: |
02 Feb 2019 13:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/3555 |
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