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Martin, Lea (2019) AN FMRI STUDY OF THE IMPACT OF OLFACTORY CUES ON CIGARETTE CRAVING. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Cigarette smoking remains the number one preventable cause of death in the United States. Cigarette craving during a quit attempt has been linked to relapse, suggesting it is a clinically significant construct. This study investigated an understudied method of craving reduction, involving the administration of olfactory cues after craving induction. Olfactory cues may work to combat craving because they strongly engage attentional and emotional processing, can induce vivid autobiographical memory (AM) recall, and because olfactory processing brain regions overlap with regions involved in craving. Using both general linear model (GLM) and multivoxel pattern analysis (MVPA) approaches, this study collected fMRI and behavioral data to build upon a set of behavioral studies that have found odors to be an effective craving reduction tool. The neural response during a strong craving state was assessed in 39 adult daily smokers across a variety of craving, olfactory, and AM regions before and after an odor exposure paradigm, during which half of the participants smelled a pleasant odor cue and half smelled a neutral odor. Results indicate that exposure to a pleasant odor cue (compared to a neutral odor cue) changed the neural response in craving related regions. Odor characteristics, namely specific memory association for an odor, and individual differences in attention to odors were found to influence this odor-induced craving change. In addition, this study found that MVPA techniques are compatible with the unique study design requirements of craving research. Study limitations, implications, and possible future directions are discussed in light of these findings.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Martin, Lealeamariamartin@gmail.comlmm1940000-0002-5321-5051
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSayette,
Committee MemberFiez,
Committee MemberKasey,
Committee MemberTristen,
Committee MemberMarc,
Date: 20 June 2019
Date Type: Publication
Defense Date: 11 January 2019
Approval Date: 20 June 2019
Submission Date: 3 January 2019
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 109
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: fMRI, olfaction, cigarette craving, MVPA
Date Deposited: 20 Jun 2019 16:27
Last Modified: 20 Jun 2019 16:27


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