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Early prediction of critical events in infants with single ventricle physiology in critical care using routinely collected data

Ruiz Herrera, Victor (2019) Early prediction of critical events in infants with single ventricle physiology in critical care using routinely collected data. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Intensive care units (ICUs) provide care for critically-ill patients who require constant monitoring and the availability of specialized equipment and personnel. In this environment, a high volume of information and a high degree of uncertainty present a burden to clinicians. In specialized cohorts, such as pediatric patients with congenital heart defects (CHDs), this burden is exacerbated by increased complexity, the inadequacy of existing decision support aids, and the limited and decreasing availability of highly-specialized clinicians.
Among CHD patients, infants with single ventricle (SV) physiology are one of the most complex and severely-ill sub-populations. While SV mortality rates have dropped, patient deterioration may happen unexpectedly in the period before patients undergo stage-2 palliative surgery. Even in expert hands, critical and potentially catastrophic events (CEs), such as cardiopulmonary resuscitation (CPR), emergent endotracheal intubation (EEI), or extracorporeal membrane oxygenation (ECMO) are common in SV patients, and may negatively impact morbidity, mortality, and hospital length of stay.
There is a clinical need of predictive tools that help intensivists assess and forecast the advent of CEs in SV infants. Although ubiquitous, widely adopted ICU severity-of-illness scores or early warning systems (EWS), e.g., PRISM and PIM, have not met this need. They are often developed for general ICU use and do not generalize well to specialized populations. Furthermore, most EWS are developed for prediction of patient mortality. Among SV patients, however, death is semi-elective. On the other hand, prediction of CEs may help clinicians improve patient care by anticipating the advent of patient deterioration.
In this dissertation, we aimed to develop and validate predictive models that achieve early and accurate prediction of CEs in infants with SV physiology. Such models may provide early and actionable information to clinicians and may be used to perform clinical interventions aimed at preventing CEs, and to reducing morbidity, mortality, and healthcare costs. We assert that our work is significant in that it addresses an unmet clinical need by achieving state-of-the-art, early prediction of patient deterioration in a challenging and vulnerable population.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Ruiz Herrera, Victorvictor.ruiz.herrera@gmail.comvmr11
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairTsui, Richtsuif@email.chop.edutsui2
Committee MemberVisweswaran, Shyamshv3@pitt.edushv3
Committee MemberLandsittel, Douglasdpl12@pitt.edudpl12
Committee MemberLopez-Magallon,
Date: 26 March 2019
Date Type: Publication
Defense Date: 11 January 2019
Approval Date: 26 March 2019
Submission Date: 22 January 2019
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 108
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Biomedical Informatics
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Congenital heart defects, hypoplastic left heart syndrome, cardiopulmonary resuscitation, endotracheal intubation, extracorporeal membrane oxygenation, risk assessment, critical event detection
Date Deposited: 26 Mar 2019 16:18
Last Modified: 26 Mar 2019 16:18


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