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Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts

Mcphaul, JJ and Dixon, FJ and Brettschneider, L and Starzl, TE (1970) Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts. New England Journal of Medicine, 282 (8). 412 - 417. ISSN 0028-4793

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Abstract

Immunofluorescent examination of open renal biopsies revealed clear-cut glomerular localization of immunoglobulins not related clearly to the quality of donor-recipient histocompatibility in 19 of 34 renal allografts. The biopsies were obtained 18 to 31 months after transplantations primarily from related donors with a variable quality of histocompatibility match. IgG was the predominant immunoglobulin class fixed in 13 biopsies, and IgM in six. The pattern of immunoglobulin deposition was linear, connoting anti-GBM antibody in four of the 19; it was granular and discontinuous, connoting antigen–antibodycomplex deposits, in 13. An immune process may affect glomeruli of renal allografts by mechanisms comparable to those that cause glomerulonephritis in native kidneys. The transplant glomerulonephritis may represent a persistence of the same disease that originally destroyed the host kidneys or the consequence of a new humoral antibody response to allograft antigens. © 1970, Massachusetts Medical Society. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Mcphaul, JJ
Dixon, FJ
Brettschneider, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 19 February 1970
Date Type: Publication
Journal or Publication Title: New England Journal of Medicine
Volume: 282
Number: 8
Page Range: 412 - 417
DOI or Unique Handle: 10.1056/nejm197002192820802
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0028-4793
Other ID: uls-drl:31735062108125, Starzl CV No. 208
Date Deposited: 08 Apr 2010 17:03
Last Modified: 30 Oct 2017 23:56
URI: http://d-scholarship.pitt.edu/id/eprint/3594

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