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Neural State Changes in Primate Motor Cortex During Arm Movements with Distinct Control Requirements

Suway, Steven B (2019) Neural State Changes in Primate Motor Cortex During Arm Movements with Distinct Control Requirements. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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The primary motor cortex (M1) is an important structure of the motor system that contributes to
many aspects of movement. Firing patterns of M1 neurons can be surprisingly complex, and there
is substantial interest in understanding these patterns and their relation to behavior. Here, we
characterize the temporal structure of M1 activity during reaching in several ways. First, we show
that single neurons encode movement information in a series of discrete segments. Information is
stably encoded during each brief segment, and the firing patterns of most neurons transition
between segments at similar times during movement. This pattern may therefore reflect transitions
between different neural “states.” Next, we establish that the sequence of states observed during
behavior is related to a sequence of distinct drivers, including visuospatial information and visual
feedback from a movement. If no feedback is provided, neurons may produce a truncated response
sequence. Last, we link the temporal structure of firing patterns to the structure of reaches and
demonstrate that the classical two-component model of reaching is reflected in M1 activity. Our
findings may help establish a useful framework for interpreting seemingly complex neural activity
during behavior.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Suway, Steven Bsbs45@pitt.edusbs45
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorSchwartz, Andrew
Committee ChairStrick, Peter
Committee MemberKass, Robert
Committee MemberOlson, Carl
Committee MemberStauffer, William
Date: 5 March 2019
Date Type: Publication
Defense Date: 23 January 2019
Approval Date: 5 March 2019
Submission Date: 11 February 2019
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 199
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurobiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: motor systems; motor cortex; multi-electrode array; macaque; reaching; neural states; neural encoding
Date Deposited: 05 Mar 2019 19:47
Last Modified: 05 Mar 2019 19:47


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