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Clotting Changes, Including Disseminated Intravascular Coagulation, during Rapid Renal-Homograft Rejection

Starzl, TE and Boehmig, HJ and Amemiya, H and Wilson, CB and Dixon, FJ and Giles, GR and Simpson, KM and Halgrimson, CG (1970) Clotting Changes, Including Disseminated Intravascular Coagulation, during Rapid Renal-Homograft Rejection. New England Journal of Medicine, 283 (8). 383 - 390. ISSN 0028-4793

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Abstract

One of two patients in whom early homograft rejection developed after renal transplantation had many antidonor antibodies before operation. By the measurement of gradients across intracorporeal and extracorporeal homografts in this patient, the new kidneys were shown to sequester host immunoglobulins, platelets, white cells and clotting factors. Moreover, the renal venous blood then contained fibrinolytic activity. This presensitized recipient, as well as a second patient who did not have detectable preformed humoral antibodies, gave evidence from clinical observation and from the various clotting tests of disseminated intravascular coagulation with fibrinolysis and a severe bleeding diathesis. Immunofluorescent and histologic studies revealed a laying down of fibrin in the homograft vessels that continued in some cases to cortical necrosis of the transplanted kidneys or, alternatively, receded at the time fibrinolysis occurred. The variety of rejection seen in these patients has been characterized as an immunologically induced coagulopathy. © 1970, Massachusetts Medical Society. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Boehmig, HJ
Amemiya, H
Wilson, CB
Dixon, FJ
Giles, GR
Simpson, KM
Halgrimson, CG
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 20 August 1970
Date Type: Publication
Journal or Publication Title: New England Journal of Medicine
Volume: 283
Number: 8
Page Range: 383 - 390
DOI or Unique Handle: 10.1056/nejm197008202830801
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0028-4793
Other ID: uls-drl:31735062108216, Starzl CV No. 218
Date Deposited: 08 Apr 2010 17:03
Last Modified: 14 Oct 2017 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/3604

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