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Modification of hyperacute canine renal homograft and pig-to-dog heterograft rejection by the intra-arterial infusion of citrate

Kux, M and Boehmig, HJ and Amemiya, H and Torisu, M and Yokoyama, T and Launois, B and Popovtzer, M and Wilson, CB and Dixon, FJ and Starzl, TE (1971) Modification of hyperacute canine renal homograft and pig-to-dog heterograft rejection by the intra-arterial infusion of citrate. Surgery, 70 (1). 103 - 112. ISSN 0039-6060

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Abstract

Hyperacute rejection was studied in seven presensitized canine recipients of renal homografts and in 22 canine recipients of pig kidneys. Under both experimental circumstances, untreated animals rejected the grafts within a few minutes. With the intra-arterial infusion of sodium citrate, hyperacute heterograft rejection was forestalled for the duration of therapy, and with homografts the benefit outlasted treatment by many hours. The protection of heterografts was not due solely to anticoagulation by the citrate, since heparin in large doses did not accomplish the same thing. A contributory factor may have been complement inhibition since removal of complement by the grafts was greatly reduced in the citrate-treated animals. © 1971.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kux, M
Boehmig, HJ
Amemiya, H
Torisu, M
Yokoyama, T
Launois, B
Popovtzer, M
Wilson, CB
Dixon, FJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1971
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 70
Number: 1
Page Range: 103 - 112
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062108497, Starzl CV No. 246
Date Deposited: 08 Apr 2010 17:04
Last Modified: 25 Nov 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/3632

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