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Goodpasture's Syndrome: Treatment With Nephrectomy and Renal Transplantation

Halgrimson, CG and Wilson, CB and Dixon, FJ and Penn, I and Anderson, JT and Ogden, DA and Starzl, TE (1971) Goodpasture's Syndrome: Treatment With Nephrectomy and Renal Transplantation. Archives of Surgery, 103 (2). 283 - 289. ISSN 0004-0010

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Three young male patients developed acute glomerulonephritis and serious hemoptysis. All three had evidence of antiglomerular basement membrane (anti-GBM) antibodies in their serum and native kidneys. The pulmonary hemorrhages ceased after bilateral nephrectomy and splenectomy accompanied by irregular treatment with steroids and other immunosuppressants. Renal homotransplantation was successfully carried out from 95 to 162 days later, after circulating anti-GBM antibodies had disappeared. Two of the homografts were biopsied and the third was removed 20, 34, and 2 months posttransplantation, respectively, and contained little or no immunoglobulin. Therefore, Goodpasture's syndrome does not contraindicate renal transplantation under the stipulated conditions of staged therapy. © 1971, American Medical Association. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Halgrimson, CG
Wilson, CB
Dixon, FJ
Penn, I
Anderson, JT
Ogden, DA
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1971
Date Type: Publication
Journal or Publication Title: Archives of Surgery
Volume: 103
Number: 2
Page Range: 283 - 289
DOI or Unique Handle: 10.1001/archsurg.1971.01350080199031
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0004-0010
Other ID: uls-drl:31735062108554, Starzl CV No. 251
Date Deposited: 08 Apr 2010 17:04
Last Modified: 02 Feb 2019 13:58


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