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Serum parathyroid hormone levels and renal handling of phosphorus in patients with chronic renal disease

Popovtzer, MM and Pinggera, WF and Hutt, MP and Robinette, J and Halgrimson, CG and Starzl, TE (1972) Serum parathyroid hormone levels and renal handling of phosphorus in patients with chronic renal disease. Journal of Clinical Endocrinology and Metabolism, 35 (2). 213 - 218. ISSN 0021-972X

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Abstract

In eight patients with advanced renal insufficiency (inulin clearance 1.4-9.1 ml/min), concentrations of serum calcium (S[Ca]) and phosphorus (S[P] ) were maintained normal (S[Ca] > 9.0 mg/100 ml, (S[P] < 3.5 mg/100 ml) for at least 20 consecutive days with phosphate binding antacids and oral calcium carbonate. The initial serum levels of immunoreactive parathyroid hormone (S-PTH) were elevated in three (426-9230 pg/ml), normal in four (one after subtotal parathyroidectomy), and not available in one. The initial fractional excretion of filtered phosphorus was high in all and ranged from 0.45-1.05. Following sustained normo-calcemia and normo-phosphatemia, S-PTH was reduced below control levels in all patients; being normal in six and elevated in two. decreased below control levels in all patients; it remained high in six (of which five had normal S-PTH) and was normal in two (of which one had elevated S-PTH). The observed relationship between S-PTH and could either reflect the inability of the radioimmunoassay for PTH employed to measure a circulating molecular species of PTH which was present in which case the actual levels of S-PTH were higher than those measured, and/or it could be indicative of the presence of additional important factor(s) (other than S-PTH) which inhibit tubular reabsorption of phosphorus in advanced chronic renal failure. © 1972 by The Endocrine Society.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Popovtzer, MM
Pinggera, WF
Hutt, MP
Robinette, J
Halgrimson, CG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1972
Date Type: Publication
Journal or Publication Title: Journal of Clinical Endocrinology and Metabolism
Volume: 35
Number: 2
Page Range: 213 - 218
DOI or Unique Handle: 10.1210/jcem-35-2-213
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0021-972X
Other ID: uls-drl:31735062108570, Starzl CV No. 253
Date Deposited: 08 Apr 2010 17:04
Last Modified: 16 Oct 2017 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/3639

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