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CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

Starzl, TE and Penn, I and Schroter, G and Putnam, CW and Halgrimson, CG and Martineau, G and Amemiya, H and Groth, CG (1971) CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION. The Lancet, 298 (7715). 70 - 74. ISSN 0140-6736

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Abstract

Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided. © 1971.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Penn, I
Schroter, G
Putnam, CW
Halgrimson, CG
Martineau, G
Amemiya, H
Groth, CG
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 10 July 1971
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 298
Number: 7715
Page Range: 70 - 74
DOI or Unique Handle: 10.1016/s0140-6736(71)92046-0
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062108612, Starzl CV No. 257
PubMed ID: 4103984
Date Deposited: 08 Apr 2010 17:04
Last Modified: 25 Nov 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/3643

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