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The complement system in renal homograft recipients

Yokoyama, T and Torisu, M and Durst, AL and Schroter, G and Groth, CG and Starzl, TE (1972) The complement system in renal homograft recipients. Surgery, 72 (4). 611 - 618. ISSN 0039-6060

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The whole serum complement and its components were studied in 24 recipients of 27 renal homografts. In 12 of 13 instances in which homograft rejection was diagnosed, it was accompanied by significant declines in CH50, IA50, C4, and C3 levels, and to a lesser degree in C1 and C2 levels. Fourteen patients had normal graft function during the postoperative course of study, and in 13 of the 14 the complement levels were within the normal range throughout. In two recipients with systemic lupus erythematosus, very low initial complement levels increased to normal levels following removal of the native kidneys, splenectomy, and the provision of a well-functioning homograft. Anticomplement activity and elevated titers of C1 and C3 inactivators were observed in some patients, but these did not correlate with the changes in CH50. The findings confirm that the complement system participates in renal homograft rejection. © 1972.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Yokoyama, T
Torisu, M
Durst, AL
Schroter, G
Groth, CG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1972
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 72
Number: 4
Page Range: 611 - 618
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062108687, Starzl CV No. 264
Date Deposited: 08 Apr 2010 17:04
Last Modified: 02 Feb 2019 13:55


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