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Acute Alteration of Plasma Renin Activity by Large Doses of Intravenous Prednisolone

Katz, FH and Popovtzer, MM and Pinggera, WF and Halgrimson, CG and Starzl, TE (1972) Acute Alteration of Plasma Renin Activity by Large Doses of Intravenous Prednisolone. Proceedings of the Society for Experimental Biology and Medicine, 141 (3). 887 - 889. ISSN 0037-9727

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Abstract

Large doses of intravenous glucocorticoids have been used in an attempt to reverse homograft rejection. The intravenous administration of 1 g prednisolone over 1 hr resulted in a significant acute reduction of plasma renin activity in 5 normal subjects tested and in 11 out of 15 patients bearing renal homografts. No definite explanation for failure to respond nor the mechanism of this prednisolone effect is readily at hand. An acute decrease in renin activity could be salutary for the chronically or acutely rejecting patient in that it could reduce vasopressor and salt-retaining effects. However, several of the non-responders had an increase in renin activity which could have been detrimental. © 1972, SAGE Publications. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Katz, FH
Popovtzer, MM
Pinggera, WF
Halgrimson, CG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1972
Date Type: Publication
Journal or Publication Title: Proceedings of the Society for Experimental Biology and Medicine
Volume: 141
Number: 3
Page Range: 887 - 889
DOI or Unique Handle: 10.3181/00379727-141-36894
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0037-9727
Other ID: uls-drl:31735062108703, Starzl CV No. 266
Date Deposited: 08 Apr 2010 17:04
Last Modified: 14 Oct 2017 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/3652

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