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Examining the effect of tumor features, BDNF, and 5-HTT genotypes on depressive symptoms in breast cancer

Wang, Justine (2019) Examining the effect of tumor features, BDNF, and 5-HTT genotypes on depressive symptoms in breast cancer. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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The development of depressive symptoms in women with breast cancer is multifactorial and may be impacted by both genetics and pathologic tumor features. The purpose of this study is to examine the contributions of the serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes to the development of depressive symptoms in postmenopausal women with early-stage breast cancer. Another aim is to investigate the impact of pathologic tumor features on the development of depressive symptoms. N=258 women (n=162 women with breast cancer and n=96 matched healthy controls) were included in the genetic aims of this study, and N=329 women with breast cancer were included in the pathologic tumor features analysis. Depressive symptomology was measured using the Beck Depression Inventory (BDI – II) at baseline, and six months and 12 months post-baseline. Linear and logistic regression models were built both with and without control for treatment group as a predictor. Participants with a SERT genotype of LA/LA had significantly higher mean BDI-II scores across time compared to all other SERT genotypes. No significant associations were found between BDNF genotype and depressive symptoms. A high Ki67 classification was associated with decreased depressive symptoms, while multifocal tumors and increased HER2 classification were associated with increased depressive symptoms. Our results support a previous study conducted at the University of Pittsburgh School of Nursing suggesting that the LA allele is a risk factor for depressive symptoms in women with breast cancer. In addition, pathologic tumor features that have previously been associated with poorer cognitive performance were similarly implicated in depressive symptom development.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Wang, Justinejuw62@pitt.edujuw62
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairConley, Yvetteyconley@pitt.eduyconley
Committee MemberBender, Catherinecbe100@pitt.educbe100
Committee MemberWesmiller, Susanswe100@pitt.eduswe100
Committee MemberKoleck,
Date: 23 April 2019
Date Type: Publication
Defense Date: 29 March 2019
Approval Date: 23 April 2019
Submission Date: 17 April 2019
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 41
Institution: University of Pittsburgh
Schools and Programs: School of Nursing > Nursing
David C. Frederick Honors College
Degree: BSN - Bachelor of Science in Nursing
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: breast cancer, depressive symptoms, serotonin transporter, BDNF, tumor
Date Deposited: 23 Apr 2019 19:51
Last Modified: 23 Apr 2020 05:15


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