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Cyclophosphamide and human organ transplantation.

Starzl, TE and Halgrimson, CG and Penn, I and Martineau, G and Schroter, G and Amemiya, H and Putnam, CW and Groth, CG (1971) Cyclophosphamide and human organ transplantation. In: UNSPECIFIED UNSPECIFIED, 70 - 74. ISBN UNSPECIFIED

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Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2–3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.


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Item Type: Book Section
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Halgrimson, CG
Penn, I
Martineau, G
Schroter, G
Amemiya, H
Putnam, CW
Groth, CG
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 10 July 1971
Date Type: Publication
Journal or Publication Title: Lancet
Volume: 2
Number: 7715
Page Range: 70 - 74
DOI or Unique Handle: 10.1016/s0140-6736(71)92046-0
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Administration, Oral, Adolescent, Adult, Animals, Antilymphocyte Serum, Azathioprine, Cadaver, Consanguinity, Cyclophosphamide, Drug Synergism, Female, Follow-Up Studies, Graft Rejection, Histocompatibility, Horses, Humans, Immunosuppressive Agents, Injections, Intramuscular, Kidney Transplantation, Liver Transplantation, Male, Middle Aged, Postoperative Complications, Prednisone, Time Factors, Transplantation Immunology, Transplantation, Homologous
ISSN: 0140-6736
Funders: NIAAA NIH HHS (A-6344), NCRR NIH HHS (M01 RR000051), NCRR NIH HHS (M01 RR000069)
Other ID: uls-drl:31735062108786, Starzl CV No. 273
Date Deposited: 08 Apr 2010 17:04
Last Modified: 03 Dec 2022 13:58


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