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Acute pancreatitis and hyperamylasemia in renal homograft recipients.

Penn, I and Durst, AL and Machado, M and Halgrimson, CG and Booth, AS and Putman, CW and Groth, CG and Starzl, TE (1972) Acute pancreatitis and hyperamylasemia in renal homograft recipients. Arch Surg, 105 (2). 167 - 172. ISSN 0004-0010

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In a series of 301 renal homograft recipients, 17 (5.6%) had acute pancreatitis at some time after transplantation. Eleven of these patients died, for a mortality of 64.7%. In each instance, pancreatitis was a major factor in a complex chain of lethal events to which immunosuppression invariably contributed. An additional 43 patients (14.3%) developed asymptomatic hyperamylasemia after transplantation and, undoubtedly, some of these recipients also had pancreatitis. The factors causing pancreatitis in the renal transplantation patient include uremia, hyperparathyroidism, pancreatic injury by drugs, infections resulting from chronic immunosuppression, gallstones, and operative trauma to the pancreas. In cases of preexisting pancreatitis, transplantation is not necessarily precluded, but efforts should be made to find a specific cause of the pancreatitis and take corrective measures, such as biliary tract surgery or parathyroidectomy if indicated, in advance of transplantation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Penn, I
Durst, AL
Machado, M
Halgrimson, CG
Booth, AS
Putman, CW
Groth, CG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: August 1972
Date Type: Publication
Journal or Publication Title: Arch Surg
Volume: 105
Number: 2
Page Range: 167 - 172
DOI or Unique Handle: 10.1001/archsurg.1972.04180080021004
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adolescent, Adult, Amylases, Azathioprine, Calcium, Cholelithiasis, Creatinine, Female, Humans, Hyperparathyroidism, Immunosuppressive Agents, Infections, Kidney Transplantation, Male, Middle Aged, Pancreatitis, Postoperative Complications, Prednisone, Transplantation Immunology, Transplantation, Homologous, Uremia
ISSN: 0004-0010
Funders: NCRR NIH HHS (M01 RR000051), NCRR NIH HHS (M01 RR000069), NIDDK NIH HHS (R01 AM007772), NIADDK NIH HHS (R01 AM007772)
Other ID: uls-drl:31735062108828, Starzl CV No. 277
PubMed ID: 4557978
Date Deposited: 08 Apr 2010 17:04
Last Modified: 03 Dec 2022 13:59


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