Shao, Huiling
(2019)
Computational Investigations of Ruthenium-Catalyzed Olefin Metathesis and Rhodium-Catalyzed Olefin Hydroboration Reactions.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
Transition metal catalysis has proven to be a powerful strategy for olefin functionalization and polymerization reactions. Ancillary ligands play an important role in controlling the reactivity and selectivity of these catalytic reactions. Mechanistically guided rational design of ancillary ligands to achieve desired reaction outcomes has been a long-standing challenge in transition metal catalyzed olefin hydrofunctionalization and metathesis reactions because multiple properties of the ligand, including electron donating ability, steric hindrance, and ligand flexibility, could contribute simultaneously to affect the reaction mechanism, reactivity, and selectivity. To date, development of new catalytic systems has been largely dependent on trial-and-error, as well as chemical intuition. Computational investigation is emerging as an effective tool to provide molecular level understanding of reaction mechanisms, substrate effects, and ligand effects. These theoretical insights can rationalize experimental observations and facilitate ligand design. In this thesis, I present a series of computational studies to probe ligand effects in transition metal catalyzed olefin metathesis and hydroboration reactions. The specific catalytic systems investigated include effects of phosphine ligands on the initiation rate of 2nd generation Grubbs catalyst, effects of switchable N-heterocyclic carbene (NHC) ligands on reactivity of Ru-catalyzed ring-opening metathesis polymerization reactions, and effects of NHC, phosphine, and asymmetric phosphite ligands on reactivity, regio-, and stereoselectivity of Rh-catalyzed olefin hydroboration reactions.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
21 June 2019 |
| Date Type: |
Publication |
| Defense Date: |
28 February 2019 |
| Approval Date: |
21 June 2019 |
| Submission Date: |
15 June 2019 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
130 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Olefin hydrofunctionalization, Organometallics, DFT, Computaitonal, Mechanism |
| Date Deposited: |
21 Jun 2019 16:21 |
| Last Modified: |
21 Jun 2019 16:21 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/36938 |
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