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The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

Starzl, TE and Francavilla, A and Halgrimson, CG and Francavilla, FR and Porter, KA and Brown, TH and Putnam, CW (1973) The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surgery Gynecology and Obstetrics, 137 (2). 179 - 199. ISSN 0039-6087

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Abstract

The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has the anabolic effect of stimulating gluconeogenesis. The insulin glucagon relationship and the interrelationship of these hormones to others, such as epinephrine, in the moment to moment regulation of nutrient and hepatic homeostasis is a central fact of liver physiology that should reconcile a number of previously divergent opinions about portoprival syndromes, mechanisms of hepatic atrophy and hyperplasia, and the control of liver regeneration.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Francavilla, A
Halgrimson, CG
Francavilla, FR
Porter, KA
Brown, TH
Putnam, CW
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 1973
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 137
Number: 2
Page Range: 179 - 199
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062109131, Starzl CV No. 308
Date Deposited: 08 Apr 2010 17:05
Last Modified: 14 Oct 2017 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/3694

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