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Correction of coagulation in the hemophilic dog by transplantation of lymphatic tissue

Groth, CG and Hathaway, WE and Gustafsson, A and Geis, WP and Putnam, CW and Björkén, C and Porter, KA and Starzl, TE (1974) Correction of coagulation in the hemophilic dog by transplantation of lymphatic tissue. Surgery, 75 (5). 725 - 733. ISSN 0039-6060

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Abstract

Available data concerning the non-hepatic source of plasma factor VIII are conflicting. In the present study, dogs with factor VIII deficiency hemophilia were transplanted with spleen or vascularized lymph node grafts obtained from normal donor dogs. Postoperative immunosuppression was done with azathioprine and heterologous antilymphocyte globulin. Four spleen transplants were successful and the recipients had positive technetium sulfide spleen scans along with adequate plasma factor VIII levels for three to eight weeks. Cessation of graft isotope uptake was accompanied by prompt disappearance of plasma factor in all four dogs. Histologically, the grafts were rejected at this time. In one dog, a second spleen graft immediately restored therapeutic factor VIII levels. Four lymph node transplants were successful and plasma factor VIII was detected for one, one, two, and ten weeks. Three dogs rejected their lymph node grafts with disappearance of factor VIII, while one had a viable transplant removed with loss of factor VIII within two days. The data suggest that factor VIII is produced in the lymphatic tissue of the dog. © 1974.


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Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Groth, CG
Hathaway, WE
Gustafsson, A
Geis, WP
Putnam, CW
Björkén, C
Porter, KA
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1974
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 75
Number: 5
Page Range: 725 - 733
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062109289, Starzl CV No. 324
Date Deposited: 08 Apr 2010 17:05
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3710

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