Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Metabolic bone disease in chronic renal failure. II. Renal transplant patients.

Huffer, WE and Kuzela, D and Popovtzer, MM and Starzl, TE (1975) Metabolic bone disease in chronic renal failure. II. Renal transplant patients. Am J Pathol, 78 (3). 385 - 400. ISSN 0002-9440

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Trabecular vertebral bone of renal transplant patients was quantitatively compared with bone from normal individuals and dialyzed and nondialyzed patienets with chronic renal failure reported in detail in an earlier study. Long- and short-term transplant patients have increased bone resorption and mineralization defects similar to renal osteodystrophy in dialyzed and nondialyzed patients. However, in transplant patients the magnitude of resorption is greater, and bone volume tends to decrease rather than increase. Resorptive activity in transplant patients is maximal during the first year after transplantation. Bone volume decreases continuously for at least 96 months after transplantation. Only decreased bone volume correlated with success or failure of the renal transplant. Morphologic findings in this study correlate with other clinical and morphologic data to suggest that reduction in bone volume in transplant patients results from a combination of persistent hyperparathyroidism and suppression of bone formation by steroid therapy.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Huffer, WE
Kuzela, D
Popovtzer, MM
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: March 1975
Date Type: Publication
Journal or Publication Title: Am J Pathol
Volume: 78
Number: 3
Page Range: 385 - 400
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Bone Diseases, Bone Resorption, Graft Rejection, Humans, Kidney Failure, Chronic, Kidney Transplantation, Lumbar Vertebrae, Middle Aged, Minerals, Osteoporosis, Renal Dialysis, Time Factors, Transplantation, Homologous
ISSN: 0002-9440
Other ID: uls-drl:31735062109404, Starzl CV No. 338
Date Deposited: 08 Apr 2010 17:05
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3724

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item