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EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS

Starzl, TE and Porter, KA and Watanabe, K and Putnam, CW (1976) EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS. The Lancet, 307 (7964). 821 - 825. ISSN 0140-6736

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Abstract

Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and trebled cell renewal. Glucagon alone had no effect. In small doses, glucagon did not potentiate the action of insulin and in large doses it may have reduced the insulin benefit. These studies explain the development of the previously mysterious Eck fistula syndrome, provide clues about in-vivo cell growth control by hormones, and suggest new lines of inquiry about the pathogenesis and/or treatment of several human disease processes. © 1976.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Porter, KA
Watanabe, K
Putnam, CW
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 17 April 1976
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 307
Number: 7964
Page Range: 821 - 825
DOI or Unique Handle: 10.1016/s0140-6736(76)90477-3
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062109701, Starzl CV No. 369
Date Deposited: 08 Apr 2010 17:06
Last Modified: 14 Oct 2017 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/3755

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