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Urine plasmin-like substances as an index of kidney allograft rejections.

Fukao, K and Kashiwagi, N and Kajiwara, T and Ishikawa, M and Husberg, B and Weil, R and Starzl, TE (1977) Urine plasmin-like substances as an index of kidney allograft rejections. Transplantation, 23 (5). 407 - 413. ISSN 0041-1337

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Using solid state radioimmunoassays developed by the first author, changes in the urine level of plasmin-like substances (PLS) and fibrin degradation products (FDP) before and after human kidney transplantation were determined in 49 transplant patients. Averages of urine PLS and FDP in a normal population of 51 persons were 0.13+/-0.10 (SD) and 0.14+/-0.07 microng/ml, respectively. In all transplant patients there was an initial rise of both PLS and FDP in urine immediately after transplantation. This elevation peaked on days 4 and 5 and the PLS and FDP levels returned to normal range within 2 weeks in patients without evidence of rejeciton. A secondary rise of urine PLS was detected before or with a rise in serum creatinine in all of the patients experiencing rejections. Of 11 patients who showed a rejection episode within 2 weeks of transplantation, the secondary rise of urine PLS was detectable in 55% of the patients slightly before the serum creatinine level changes; of 6 patients with a rejection episode more than 2 weeks after transplantation, 100% showed a secondary PLS rise 6.7+/-2.3 (SE) days before the serum creatinine increased. The appearance of the secondary rise of urine FDP in the rejecting recipients was slightly later than the rise of PLS. Serial determination of urine PLS levels following human kidney transplantation appears to be an early index of rejections which occurs more than 2 weeks after transplantation, although the clinical usefulness of this measurement is probably limited.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Fukao, K
Kashiwagi, N
Kajiwara, T
Ishikawa, M
Husberg, B
Weil, R
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: May 1977
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 23
Number: 5
Page Range: 407 - 413
DOI or Unique Handle: 10.1097/00007890-197705000-00005
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Creatinine, Fibrin Fibrinogen Degradation Products, Fibrinolysin, Graft Rejection, Humans, Kidney Transplantation, Time Factors, Transplantation, Homologous
ISSN: 0041-1337
Funders: NCRR NIH HHS (M01 RR000051), NCRR NIH HHS (M01 RR000069), NIDDK NIH HHS (R01 AM007772), NIADDK NIH HHS (R01 AM007772)
Other ID: uls-drl:31735062109784, Starzl CV No. 377
Date Deposited: 08 Apr 2010 17:06
Last Modified: 16 Jul 2019 15:56


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