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Progress in liver transplantation.

Putnam, CW and Halgrimson, CG and Koep, L and Starzl, TE (1977) Progress in liver transplantation. World J Surg, 2 (1). 165 - 175. ISSN 0364-2313

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Since the first clinical orthotopic liver transplant was performed 13 years ago, approximately 275 patients have undergone this procedure. The Denver series constitutes about 40% of this total experience. In our series, the overall 1-year survival has been 29%; the longest survivor is now 62/3 years posttransplantation. Most of the early deaths have been caused by technical complications, frequently related to difficulties in establishing and maintaining adequate biliary drainage. The late deaths have been from a variety of causes, including recurrent tumor, hepatitis, bile duct obstruction, and chronic rejection. Favorable indications for liver transplantation include biliary atresia, chronic aggressive hepatitis, inborn errors of metabolism, and certain other benign hepatic diseases. Alcoholic cirrhosis is a less favorable indication and primary hepatic malignancy is a relative contraindication. The immunologic criteria for donor-recipient selection are much less rigid than for renal transplantation. Biliary reconstruction is the principal technical problem encountered with orthotopic liver transplantation. Guidelines for the establishment of biliary drainage, its evaluation, and the management of postoperative biliary complications are discussed.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Putnam, CW
Halgrimson, CG
Koep, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: March 1977
Date Type: Publication
Journal or Publication Title: World J Surg
Volume: 2
Number: 1
Page Range: 165 - 175
DOI or Unique Handle: 10.1007/bf01665073
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Biliary Tract, Chronic Disease, Common Bile Duct, Drainage, Gallbladder, Graft Rejection, Hepatitis, Humans, Immunologic Techniques, Liver Cirrhosis, Liver Neoplasms, Liver Transplantation, Metabolism, Inborn Errors, Transplantation, Homologous
ISSN: 0364-2313
Funders: NCRR NIH HHS (M01 RR000051), NCRR NIH HHS (M01 RR000069), NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062109834, Starzl CV No. 382
Date Deposited: 08 Apr 2010 17:06
Last Modified: 03 Dec 2022 13:58


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