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A 14-year experience with kidney transplantation.

Weil, R and Schröter, GP and West, JC and Starzl, TE (1977) A 14-year experience with kidney transplantation. World J Surg, 2 (1). 145 - 156. ISSN 0364-2313

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Abstract

Between November, 1962 and August, 1975, 668 kidney transplants were done in 556 consecutive patients at Denver, Colorado. The Denver experience has been divided into 7 periods of time, according to the conditions of care during each period. The results in related transplantation have changed little during the decade beginning in 1966. The results in unrelated transplantation have not materially changed since 1968. The long-term patient survival after related transplantation has been better than after cadaver transplantation. The results of transplantation in 57 children ages 3 to 18 years have been slightly better than the results of adult transplantation. The outcome of kidney transplantation and the feasibility of improving this therapy with present techniques are limited by our inability to accurately match each patient with the immunologically best donor and by our inability to precisely control the immune system of the recipient. Rejection is still the main reason for graft loss, and sepsis remains the main cause of patient mortality. More specific and less toxic means of achieving graft acceptance are needed before a higher level of patient service can be realized. However, even with the tools now available, thousands of recipients throughout the world have been returned to useful lives.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Weil, R
Schröter, GP
West, JC
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: March 1977
Date Type: Publication
Journal or Publication Title: World J Surg
Volume: 2
Number: 1
Page Range: 145 - 156
DOI or Unique Handle: 10.1007/bf01665068
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Cadaver, Child, Graft Survival, Histocompatibility Testing, Humans, Immunosuppression Therapy, Kidney Transplantation, Lymphocyte Culture Test, Mixed, Organ Preservation, Transplantation Immunology, Transplantation, Homologous
ISSN: 0364-2313
Funders: NCRR NIH HHS (M01 RR000051), NCRR NIH HHS (M01 RR000069), NIDDK NIH HHS (R01 AM007772), NIADDK NIH HHS (R01 AM007772)
Other ID: uls-drl:31735062109842, Starzl CV No. 383
Date Deposited: 08 Apr 2010 17:06
Last Modified: 03 Dec 2022 13:58
URI: http://d-scholarship.pitt.edu/id/eprint/3769

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