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Liver regeneration in dogs: Morphologic and chemical changes

Francavilla, A and Porter, KA and Benichou, J and Jones, AF and Starzl, TE (1978) Liver regeneration in dogs: Morphologic and chemical changes. Journal of Surgical Research, 25 (5). 409 - 419. ISSN 0022-4804

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Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later. Compensatory hypertrophy and hyperplasia ("regeneration") were evident within 1 day, reached a maximum in 3 days, and were almost complete by 6 days. Coincident with the histologic events of regeneration were decreases in responsiveness of receptor adenyl cyclase to glucagon stimulation, increases of cyclic AMP, inconsistent changes in plasma insulin, and increases in plasma glucagon. These studies have standardized hepatic resection in dogs and they have focused attention upon some possible mechanisms that will require further study. © 1978 Academic Press, Inc. All rights of reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Francavilla, A
Porter, KA
Benichou, J
Jones, AF
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1978
Date Type: Publication
Journal or Publication Title: Journal of Surgical Research
Volume: 25
Number: 5
Page Range: 409 - 419
DOI or Unique Handle: 10.1016/s0022-4804(78)80005-5
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-4804
Other ID: uls-drl:31735062109974, Starzl CV No. 396
Date Deposited: 08 Apr 2010 17:06
Last Modified: 02 Feb 2019 13:56


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