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Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis

Francavilla, A and Jones, AF and Starzl, TE (1978) Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis. Gastroenterology, 75 (6). 1026 - 1032. ISSN 0016-5085

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Abstract

Glucagon was tested for its effect on plasma adenosine 3′,5′-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused a significant increase in plasma cyclic AMP, glucose, and insulin. In advanced cirrhotics, plasma cyclic AMP, glucose, and insulin did not increase. Adenylate cyclase concentration was measured in liver tissue from end stage cirrhotic patients and from brain-dead organ donors whose cardiovascular function was maintained in a stable state. Basal and total adenylate cyclase concentration were not different in the two groups. Adenylate cyclase from the livers of advanced cirrhotics was, however, significantly less responsive to glucagon stimulation than was that from donor livers. Hepatocytes in advanced cirrhosis have abnormal metabolic behavior characterized by abnormal adenylate cyclase-cyclic AMP response to hormonal stimulation. © 1978.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Jones, AF
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1978
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 75
Number: 6
Page Range: 1026 - 1032
DOI or Unique Handle: 10.1016/0016-5085(78)90070-7
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062109990, Starzl CV No. 398
Date Deposited: 08 Apr 2010 17:06
Last Modified: 23 May 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/3784

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