Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The effect of splanchnic viscera removal upon canine liver regeneration

Starzl, TE and Francavilla, A and Porter, KA and Benichou, J and Jones, AF (1978) The effect of splanchnic viscera removal upon canine liver regeneration. Surgery Gynecology and Obstetrics, 147 (2). 193 - 207. ISSN 0039-6087

Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


The influence of portal blood factors on canine liver regeneration was studied with graded nonhepatic splanchnic evisceration, coupled with 44 and 72 per cent hepatectomies. In one type of experiment, the pancreas was retained while the rest of the intra-abdominal gastrointestinal tract was removed. In a second variety, total pancreatectomy was performed with preservation of the intra-abdominal organs. In a third kind of experiment, total nonhepatic splanchnic evisceration was performed. Liver regeneration after hepatectomy was decreased by all three kinds of viscera removed as judged by deoxyribonucleic acid synthesis, autoradiography and mitotic index. Pancreatectomy and nonpancreatic splanchnic evisceration caused almost equal decreases in the regenerative response. Total nonhepatic splanchnic evisceration essentially halted regeneration during the first three postoperative days and intraportal infusions of insulin or glucagon, or both together, did not reverse this effect. The decrease in liver membrane bound adenyl cyclase activity and biphasic change in liver cyclic 3',5'-adenosine monophosphate concentrations normally seen partial hepatectomy was disrupted after the various eviscerations. Adenyl cyclase activity and cyclic monophosphate concentrations tended to be higher than normal in the eviscerated dogs. These observations provide more support for our previously proposed hypothesis that control of liver regeneration is by multiple factors. Pancreatic hormones are important modifiers of this response but by no means exercise exclusive control. Other substances of gastrointestinal origin, presumably including hormones and nutrient supply apparently play important specific roles. The volume of portal flow is a secondary and nonspecific, but possibly significant, factor.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Francavilla, A
Porter, KA
Benichou, J
Jones, AF
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 1978
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 147
Number: 2
Page Range: 193 - 207
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062110006, Starzl CV No. 399
Date Deposited: 08 Apr 2010 17:06
Last Modified: 02 Feb 2019 13:57


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item