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The effect upon the liver of evisceration with or without hormone replacement

Starzl, TE and Francavilla, A and Porter, KA and Benichou, J (1978) The effect upon the liver of evisceration with or without hormone replacement. Surgery Gynecology and Obstetrics, 146 (4). 524 - 532. ISSN 0039-6087

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Abstract

All, or nearly all, of the nonhepatic splanchnic viscera were removed in dogs. In most untreated dogs, the liver cells underwent changes similar to those caused by portacaval shunt, including structural deterioration of organelles and fatty metamorphosis. The rate of division of the hepatocytes, as measured by the mitotic index and by autoradiography, was depressed as were deoxyribonucleic acid synthesis and adenylate cyclase activity. These changes were restored to, or toward, normal with the intraportal administration of commercial or purified insulin but not with glucagon or epidermal growth factor. The results of both the pathologic and biochemical studies were consistent, except for an incongruity in some of the dogs in which the colon was retained.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Francavilla, A
Porter, KA
Benichou, J
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 1978
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 146
Number: 4
Page Range: 524 - 532
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062110048, Starzl CV No. 405
Date Deposited: 08 Apr 2010 17:06
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3791

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