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Thoracic duct drainage in organ transplantation: Will it permit better immunosuppression?

Starzl, TE and Koep, LJ and Weil, R and Halgrimson, CG and Franks, JJ (1979) Thoracic duct drainage in organ transplantation: Will it permit better immunosuppression? Transplantation Proceedings, 11 (1). 276 - 284. ISSN 0041-1345

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Abstract

It is possible that thoracic-duct drainage, a major but neglected immunosuppressive adjunct, can have an important impact on organ transplantation. If thoracic-duct drainage is started at the time of transplantation, the practicality of its use in cadaveric cases is greatly enhanced. With kidney transplantation, the penalty of not having pretreatment for the first organ is compensanted by the automatic presence of pretreatment if rejection is not controlled and retransplantation becomes necessary. The advantage of adding thoracic-duct drainage to conventional immunosuppression may greatly enhance the expectations for the transplantation of extrarenal organs, such as the liver, pancreas, heart, and lung. There is evidence that pretreatment with thoracic-duct drainage of patients with cytotoxic antibodies may permit successful renal transplantation under these otherwise essentially hopeless conditions. Exploration of the neglected but potentially valuable tool of thoracic-duct drainage seems to the authors to be highly justified in other centers.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Koep, LJ
Weil, R
Halgrimson, CG
Franks, JJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 27 November 1979
Date Type: Publication
Journal or Publication Title: Transplantation Proceedings
Volume: 11
Number: 1
Page Range: 276 - 284
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1345
Other ID: uls-drl:31735062110162, Starzl CV No. 417
Date Deposited: 08 Apr 2010 17:07
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3803

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