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GROWTH-STIMULATING FACTOR IN REGENERATING CANINE LIVER

Starzl, TE and Terblanche, J and Porter, KA and Jones, AF and Usui, S and Mazzoni, G (1979) GROWTH-STIMULATING FACTOR IN REGENERATING CANINE LIVER. The Lancet, 313 (8108). 127 - 130. ISSN 0140-6736

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Abstract

Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon. © 1979.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Terblanche, J
Porter, KA
Jones, AF
Usui, S
Mazzoni, G
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 20 January 1979
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 313
Number: 8108
Page Range: 127 - 130
DOI or Unique Handle: 10.1016/s0140-6736(79)90519-1
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062113927, Starzl CV No. 421
PubMed ID: 84151
Date Deposited: 08 Apr 2010 17:07
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/3807

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