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Liver Transplantation for Advanced Liver Disease with Alpha-1antitrypsin Deficiency

Hood, JM and Koep, LJ and Peters, RL and Schröter, GPJ and Weil, R and Redeker, AG and Starzl, TE (1980) Liver Transplantation for Advanced Liver Disease with Alpha-1antitrypsin Deficiency. New England Journal of Medicine, 302 (5). 272 - 275. ISSN 0028-4793

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Abstract

ALPHA-1-antitrypsin deficiency associated with chronic obstructive airway disease was recognized in 1963 by Laurell and Ericksson.1 In 1969, Sharp2 described the first cases of alpha-1-antitrypsin-deficiency disease in children with cirrhosis. Since then, this inborn error has been recognized as one of the more common factors in cirrhosis of infancy and childhood,3 including “neonatal hepatitis.”4 Alpha-1-antitrypsin is a glycoprotein that accounts for a major portion of the alpha-1 globulin fraction of the serum.5 It is responsible for approximately 90 per cent of the antitrypsin activity6 of the serum, and it also inhibits several other plasma enzymes, including plasmin,7 elastase,8 collagenase,9 and. © 1980, Massachusetts Medical Society. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hood, JM
Koep, LJ
Peters, RL
Schröter, GPJ
Weil, R
Redeker, AG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 31 January 1980
Date Type: Publication
Journal or Publication Title: New England Journal of Medicine
Volume: 302
Number: 5
Page Range: 272 - 275
DOI or Unique Handle: 10.1056/nejm198001313020505
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0028-4793
Other ID: uls-drl:31735062114057, Starzl CV No. 443
Date Deposited: 08 Apr 2010 17:07
Last Modified: 16 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/3829

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