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Stimulation of hepatic regeneration after partial hepatectomy by infusion of a cytosol extract from regenerating dog liver

Terblanche, J and Porter, KA and Starzl, TE and Moore, J and Patzelt, L and Hayashida, N (1980) Stimulation of hepatic regeneration after partial hepatectomy by infusion of a cytosol extract from regenerating dog liver. Surgery Gynecology and Obstetrics, 151 (4). 538 - 544. ISSN 0039-6087

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Abstract

A cytosol liver extract was prepared from adult dog livers and from liver remnants that had been regenerating for one, two and three days after 72 per cent partial hepatectomy. Given intraportally, the most active of these cytosols did not stimulate proliferation in the livers of normal dogs. However, infused during a six hour period into the portal vein of test group dogs, the cytosol from 48 and, especially, 72 hour regenerating livers augmented the regeneration response ordinarily produced by 44 per cent partial hepatectomy. The effect was delayed. It became identifiable 48 hours after infusion and reached a peak at 72 hours. Neither augmentation nor significant inhibition of the normal regeneration response was produced by cytosol from normal liver and 24 hour regenerating liver or by a six hour infusion of insulin. The amplification effect of active cytosol was equivocal when the infusions were given intraperitoneally and was not demonstrable at all by the intravenous route. In these investigations, it is confirmed that there are growth control factors in regenerating liver but the nature or physiologic significance of the factor or factors has not been clarified.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Terblanche, J
Porter, KA
Starzl, TEtes11@pitt.eduTES11
Moore, J
Patzelt, L
Hayashida, N
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 15 December 1980
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 151
Number: 4
Page Range: 538 - 544
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062114107, Starzl CV No. 446
Date Deposited: 08 Apr 2010 17:07
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3832

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