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Further studies on hepatic stimulatory substance (SS) after partial hepatectomy

Starzl, TE and Porter, KA and Hayashida, N and Schechter, P and Terblanche, J (1980) Further studies on hepatic stimulatory substance (SS) after partial hepatectomy. Journal of Surgical Research, 29 (6). 471 - 474. ISSN 0022-4804

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Abstract

The stimulatory substance (SS) that is found in the cytosol of regenerating dog livers and which promoted regeneration when injected into the portal vein after Eck fistula did not cause glomerular proliferation when active cytosol was injected into the renal artery. The finding was compatible with but did not prove organ specificity of hepatic SS. The development of SS was completely prevented by extirpation of all nonhepatic splanchnic organs at the same time as partial hepatectomy. This finding indicated that SS in the cytosol donors was a feature rather than an initiator of regeneration, and one that depended upon the collaboration of extrahepatic (including splanchnic hepatotrophic) factors. © 1980.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Porter, KA
Hayashida, N
Schechter, P
Terblanche, J
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1980
Date Type: Publication
Journal or Publication Title: Journal of Surgical Research
Volume: 29
Number: 6
Page Range: 471 - 474
DOI or Unique Handle: 10.1016/0022-4804(80)90014-1
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-4804
Other ID: uls-drl:31735062114149, Starzl CV No. 450
Date Deposited: 08 Apr 2010 17:07
Last Modified: 16 Oct 2017 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/3836

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