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Inorganic arsenic and respiratory health: an update of a systematic review

Ge, Tengziyi (2020) Inorganic arsenic and respiratory health: an update of a systematic review. Master's Thesis, University of Pittsburgh. (Unpublished)

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This systematic review updates a systematic review that synthesized inorganic arsenic exposure and respiratory health effects published in 2016. The final review added eight publications from six countries. It examined the relationship between inorganic arsenic exposure and five respiratory outcomes, including lung function, respiratory symptoms, acute respiratory infections, chronic respiratory disease, and non-malignant lung disease mortality. Emerging evidence showed a general association between InAs and non-malignant respiratory illnesses, including consistent evidence on lung function impairment, respiratory symptoms, acute respiratory tract infections, and non-malignant lung disease. Early life InAs exposure has lasting effects on the respiratory system throughout the lifespan. This review found some research gaps, including mixed evidence of sex differences, limited evidence at low-level exposure (water arsenic<100 μg/L), and uncertainty on pathogenic mechanisms in response to arsenic exposures. Limitations including potential publication bias, potential language bias, incomplete exposure histories, ecological fallacy, and non-comparability of outcome measures across publications. The public health significance of this systematic review is providing more robust epidemiologic evidence. It could be helpful and instructive for future research on the detrimental effects of arsenic on respiratory health.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Ge, Tengziyiteg30@pitt.eduteg300000-0003-4981-7989
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee MemberBarchowsky, Aaronaab20@pitt.eduaab20
Thesis AdvisorLeikauf, Georgegleikauf@pitt.edugleikauf
Committee MemberRojas,
Date: 30 July 2020
Date Type: Publication
Defense Date: 18 June 2020
Approval Date: 30 July 2020
Submission Date: 31 March 2020
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 40
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Environmental and Occupational Health
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Arsenic, drinking water, lung diseases, review
Date Deposited: 31 Jul 2020 02:23
Last Modified: 31 Jul 2020 02:23


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