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Transport of apolipoproteins A-I and A-II by human thoracic duct lymph

Anderson, DW and Schaefer, EJ and Bronzert, TJ and Lindgren, FT and Forte, T and Starzl, TE and Niblack, GD and Zech, LA and Brewer, HB (1981) Transport of apolipoproteins A-I and A-II by human thoracic duct lymph. Journal of Clinical Investigation, 67 (3). 857 - 866. ISSN 0021-9738

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Abstract

The daily transport of human plasma apolipoproteins A-I and A-II, triglyceride, and total cholesterol from the thoracic duct lymph into plasma was measured in 2 subjects before and 3 subjects after renal transplantation. Lymph triglyceride transport was ~83% of the daily ingested fat loads, whereas lymph cholesterol transport was consistently greater than the amount of daily ingested cholesterol. Lymph apolipoprotein transport significantly (P < 0.05) exceeded the predicted apolipoprotein synthesis rate by an average of 659±578 mg/d for apolipoprotein A-I and 109±59 mg/d for apolipoprotein A-II among the 5 subjects. It is estimated that 22-77% (apolipoprotein A-I) and 28-82% (apolipoprotein A-II) of daily total body apolipoprotein synthesis takes place in the intestine. Lymph high density lipoprotein particles are mostly high density lipoprotein(2b) and high density lipoprotein(2a) and have a greater overall relative triglyceride content and a smaller relative cholesteryl ester content when compared with homologous plasma high density lipoproteins. The major quantity of both lymph apolipoprotein A-I (81±8%) and apolipoprotein A-II (90±11%) was found within high density lipoproteins with almost all of the remainder found in chylomicrons and very low density lipoproteins. The combined results are consistent with a major contribution of the intestine to total body synthesis of apolipoprotein A-I and apolipoprotein A-II. An important role of lymph in returning filtered apolipoprotein to plasma in association with high density lipoproteins is proposed. Accompanying the return of filtered apolipoprotein to the plasma is a probable transformation, both in size and composition, of at least some of the lymph high density lipoprotein(2b) and high density lipoprotein(2a) particles into high density lipoprotein3.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Anderson, DW
Schaefer, EJ
Bronzert, TJ
Lindgren, FT
Forte, T
Starzl, TEtes11@pitt.eduTES11
Niblack, GD
Zech, LA
Brewer, HB
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1981
Date Type: Publication
Journal or Publication Title: Journal of Clinical Investigation
Volume: 67
Number: 3
Page Range: 857 - 866
DOI or Unique Handle: 10.1172/jci110103
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0021-9738
Other ID: uls-drl:31735062114313, Starzl CV No. 465
Date Deposited: 08 Apr 2010 17:07
Last Modified: 22 Jun 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/3851

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