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NEPHROTOXICITY OF CYCLOSPORIN A IN LIVER AND KIDNEY TRANSPLANT PATIENTS

Klintmalm, GBG and Iwatsuki, S and Starzl, TE (1981) NEPHROTOXICITY OF CYCLOSPORIN A IN LIVER AND KIDNEY TRANSPLANT PATIENTS. The Lancet, 317 (8218). 470 - 471. ISSN 0140-6736

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Abstract

In six of twelve orthotopic liver recipients nephrotoxicity was noted after 13-22 days of treatment with 16·3±2·9 (SEM) mg/kg per day of cyclosporin A (CyA). With a decrease in the daily CyA dose to 9·2±2·3 (SEM) mg/kg kidney function returned to normal. No hepatic rejections occurred on this lowered CyA dose. In 4 out of 66 kidney recipients a switch from a CyA dose of 5·2-10·7 mg/kg daily to azathioprine was done 4-8 months after transplant because of unsatisfactory kidney function, suspected to be due to nephrotoxicity. In three patients, this resulted in an improved graft function. A fourth transplant was lost to an irreversible rejection 13 days later. Thus CyA is nephrotoxic but this toxicity is easily reversed, even after many months of treatment, and the ease with which this complication can be managed suggests that nephrotoxicity should not diminish the high expectations that transplant surgeons have for CyA. © 1981.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Klintmalm, GBG
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 28 February 1981
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 317
Number: 8218
Page Range: 470 - 471
DOI or Unique Handle: 10.1016/s0140-6736(81)91851-1
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062114297, Starzl CV No. 467
PubMed ID: 6110092
Date Deposited: 08 Apr 2010 17:07
Last Modified: 14 Oct 2017 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/3853

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