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Late follow-up after thoracic duct drainage in cadaveric renal transplantation

Starzl, TE and Klintmalm, GBG and Iwatsuki, S and Weil, R (1981) Late follow-up after thoracic duct drainage in cadaveric renal transplantation. Surgery Gynecology and Obstetrics, 153 (3). 377 - 382. ISSN 0039-6087

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Thoracic duct drainage was added to conventional immunosuppression with azathioprine, prednisone and, sometimes, antilymphocyte globulin in 83 patients given cadaveric kidneys, including 65 primary graft recipients. The most effective use of thoracic duct drainage was for pretreatment. Optimal conditioning was at least four weeks duration, and when lymph drainage was this long, the incidence of rejection during the first three postoperative months was reduced to 4.5 per cent. Shorter pretreatment or institution of thoracic duct drainage contemporaneous with transplantation were less effective, but the one year results were still better than those with conventional immunosuppression alone. However, the advantage gained with thoracic duct drainage during the first year was diminished in all the treatment groups by graft losses in the second postoperative year. It was concluded that, without better maintenance therapy, the full value of temporary early lymphoid depletion procedures cannot be fully exploited.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Klintmalm, GBG
Iwatsuki, S
Weil, R
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1981
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 153
Number: 3
Page Range: 377 - 382
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062114362, Starzl CV No. 468
Date Deposited: 08 Apr 2010 17:07
Last Modified: 02 Feb 2019 13:57


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