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Lymphapheresis in organ transplantation: preliminary report.

Iwatsuki, S and Iwaki, Y and Klintmalm, G and Kano, T and Krams, AK and Starzl, TE (1982) Lymphapheresis in organ transplantation: preliminary report. In: UNSPECIFIED UNSPECIFIED, 219 - 226. ISBN UNSPECIFIED

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Abstract

Reduction of lymphoid tissue by splenectomy and/or thymectomy has been used as a part of immunosuppression in organ transplantation (4). More recently Walker (7), Johnson (2), Franksson (1) and Starzl (5,6) and their associates have shown that chronic depletion of lymphocytes by thoracic duct drainage decreases the incidence of rejection and hence increases renal graft survival. Mechanical removal of lymphocytes from circulation peripheral blood should theoretically achieve the same or similar effect on the immunity as thoracic duct drainage. Since September, 1979, five organ transplant recipients have received multiple lymphocytapheresis by IBM 2997 Blood Cell Separator as a mechanical pretransplant immunosuppression. The changes in cellular and humoral immunity and the clinical outcome are presented in this report.

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Details

Item Type: Book Section
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Iwatsuki, S
Iwaki, Y
Klintmalm, G
Kano, T
Krams, AK
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1982
Date Type: Publication
Journal or Publication Title: Progress in clinical and biological research
Volume: 88
Page Range: 219 - 226
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0361-7742
Other ID: uls-drl:31735062114446, Starzl CV No. 476
Date Deposited: 08 Apr 2010 17:08
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/3862

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