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99mTc-DTPA and 131I-hippuran findings in liver transplant recipients treated with cyclosporin A.

Klintmalm, GB and Klingensmith, WC and Iwatsuki, S and Schröter, GP and Starzl, TE (1982) 99mTc-DTPA and 131I-hippuran findings in liver transplant recipients treated with cyclosporin A. Radiology, 142 (1). 199 - 202. ISSN 0033-8419

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Abstract

The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Klintmalm, GB
Klingensmith, WC
Iwatsuki, S
Schröter, GP
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: January 1982
Date Type: Publication
Journal or Publication Title: Radiology
Volume: 142
Number: 1
Page Range: 199 - 202
DOI or Unique Handle: 10.1148/radiology.142.1.7031760
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Bilirubin, Creatinine, Cyclosporins, Humans, Iodohippuric Acid, Kidney, Liver Transplantation, Pentetic Acid, Postoperative Period, Radionuclide Imaging, Technetium, Technetium Tc 99m Pentetate
ISSN: 0033-8419
Funders: NIDDK NIH HHS (R01 AM007772), NIADDK NIH HHS (R01 AM007772)
Other ID: uls-drl:31735062114420, Starzl CV No. 478
Date Deposited: 08 Apr 2010 17:08
Last Modified: 05 Dec 2017 17:00
URI: http://d-scholarship.pitt.edu/id/eprint/3864

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