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A Numerical Investigation into the Hemodynamics, Oxygen Transport, and Flow Stability of Cerebral Aneurysms

Durka, Michael J (2020) A Numerical Investigation into the Hemodynamics, Oxygen Transport, and Flow Stability of Cerebral Aneurysms. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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A cerebral or intra-cranial aneurysm (IA) is a pathological saccular bulge occurring
in the cerebral arteries of the brain. These structures have a propensity to rupture due
to their structurally deficient arising from their pathological nature. A ruptured IA can
have disastrous or fatal consequence for a patient. Surgical intervention furthermore carries
its own innate risks. Therefore, an understanding of IA initiation, growth and rupture
remains imperative in the treatment of the disease. However, these processes remain poorly
Hemodynamics, the mechanical forces imparted on the vessel wall from the flowing blood
contained within, is thought to be a substantial contributing factor in the progression of the
disease. The study of aneurysmal hemodynamics and their impact on the aneurysm wall
remains challenging due to the inaccessibility from their location deep within the brain
that clinicians are faced with. Therefore, computational fluid dynamics (CFD) studies are
frequently utilized in the study of aneurysmal heodynamics.
The work herein focuses on advancing the study of aneurysmal hemodynamics in four
major areas. The first is an extensive categorization of the blood flow waveforms found within
the cerebral circulation from a uniquely large data-set of 272 cardiovascular patent waveforms
that quantifies the impact on the hemodynamics from the variation in this large data-set. The
second section focuses on quantifying the multi-parameter relationship between aneurysmal
geometry and intra-saccular flow-structure via parametric study. The third section explores
the impact of the pathological morphology of aneurysms on the blood’s ability to transport
oxygen to the wall tissue within the aneurysm. Finally, this work identifies geometric features
additional to those previously known which initiate pathological high-frequency fluctuations
in the blood flow and examines possible solution strategies in answering the open question
as to what impact do these flow features have on the development of IAs.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Durka, Michael Jmjd4@pitt.edumjd4
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorRobertson, Anne/
Committee MemberCebral, Juan/
Committee MemberBabaee,
Committee MemberGaldi, Giovanni/
Date: 31 July 2020
Date Type: Publication
Defense Date: 26 February 2020
Approval Date: 31 July 2020
Submission Date: 10 April 2020
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 210
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Mechanical Engineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Computational Fluid Dynamics, Cerebral Aneurysms, Hemodynamics, Oxygen Transport
Date Deposited: 31 Jul 2020 19:31
Last Modified: 23 Mar 2023 17:43


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