Loudenslager, Emilie
(2020)
The role of a PGC1-alpha variation in patient outcomes after severe traumatic brain injury.
Undergraduate Thesis, University of Pittsburgh.
(Unpublished)
Abstract
A traumatic brain injury (TBI) is damage to the brain resulting from a blow or jolt to the head. Despite enduring similar extent of injuries and receiving similar treatment measures, some individuals recover much faster than others with little to no long lasting deficits. With mechanism of injury and environment of treatment being similar, these differences in recovery could indicate a potential genetic component. This study aimed to investigate the relationship between a single nucleotide polymorphism (SNP) of PGC1-alpha and outcomes following severe TBI. PGC1-alpha is heavily involved in several metabolic processes such as mitochondrial biogenesis, fatty acid oxidation, thermogenesis and several more. Despite this genes involvement in these processes, there has been no formal investigation into the role that PGC1-alpha plays following a TBI, warranting a need for a study of this nature.
Participants (n=429) were recruited from the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital following a severe TBI with a Glasgow Coma Score ≤8 and followed for 24 months post-injury to evaluate long term outcomes. Outcomes were evaluated using the Glasgow Outcome Scale (GOS), Neurobehavioral Rating Scale (NRS), and Disability Rating Scale (DRS). Allelic Discrimination of the SNP rs8192678 was performed using a taqman assay. Individuals with the CC genotype were found to have better outcomes on the NRS at the 3 month post-injury timepoint when compared to individuals with the CT/TT genotypes. These findings show that PGC1-alpha may play a role in TBI recovery and warrants further investigation of the role PGC1-alpha plays in recovery after TBI.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Loudenslager, Emilie | ecl47@pitt.edu | ecl47 | |
|
| ETD Committee: |
|
| Date: |
4 May 2020 |
| Date Type: |
Publication |
| Defense Date: |
9 April 2020 |
| Approval Date: |
4 May 2020 |
| Submission Date: |
14 April 2020 |
| Access Restriction: |
1 year -- Restrict access to University of Pittsburgh for a period of 1 year. |
| Number of Pages: |
29 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
David C. Frederick Honors College
School of Nursing > Nursing |
| Degree: |
BSN - Bachelor of Science in Nursing |
| Thesis Type: |
Undergraduate Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Traumatic Brain Injury, Single Nucleotide Polymorphism, patient outcomes, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC1-alpha), Gly482Ser |
| Date Deposited: |
04 May 2020 21:27 |
| Last Modified: |
04 May 2021 05:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/38712 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}