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Variable convalescence and therapy after cadaveric renal transplantation under cyclosporin A and steroids

Starzl, TE and Hakala, TR and Rosenthal, JT and Iwatsuki, S and Shaw, BW (1982) Variable convalescence and therapy after cadaveric renal transplantation under cyclosporin A and steroids. Surgery Gynecology and Obstetrics, 154 (6). 819 - 825. ISSN 0039-6087

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Abstract

The postoperative convalescence period was analyzed for 42 consecutive patients who had cadaveric renal transplantation under therapy with cyclosporin A and steroids. Twenty-two of the patients underwent transplantation for the first time, and the other 20 had retransplantation. None of the recipients has died. With follow-up period of two to eight months, the survival rate of grafts is 96 per cent after first transplantation and 85 per cent after retransplantation. Immunosuppression with a standard regimen was used for all patients at the outset. Early convalescence was highly variable, often necessitating adjustments of cyclosporin A and steroid dosage to accommodate the possibilities of rejection or cyclosporin A nephrotoxicity, or both, simultaneously. Management problems were more frequent and complex in patients undergoing retransplantation. From the results, a classification of convalescence patterns was evolved, with recommendations about how standardized initial therapy should be adjusted if the renal graft does not function promptly or deteriorates later.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Hakala, TR
Rosenthal, JT
Iwatsuki, S
Shaw, BW
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 20 September 1982
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 154
Number: 6
Page Range: 819 - 825
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062114503, Starzl CV No. 486
Date Deposited: 08 Apr 2010 17:08
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/3872

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