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Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam

Du, Yijuan and Grace, Anthony A. (2016) Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam. International Journal of Neuropsychopharmacology, 19 (11). pyw065. ISSN 1461-1457

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Loss of parvalbumin interneurons in the hippocampus is a robust finding in schizophrenia brains. Rats exposed during embryonic day 17 to methylazoxymethanol acetate exhibit characteristics consistent with an animal model of schizophrenia, including decreased parvalbumin interneurons in the ventral hippocampus. We reported previously that peripubertal administration of diazepam prevented the emergence of pathophysiology in adult methylazoxymethanol acetate rats.

We used an unbiased stereological method to examine the impact of peripubertal diazepam treatment on parvalbumin interneuron number in the ventral subiculum, dentate gyrus of the hippocampus and the basolateral amygdala.

Methylazoxymethanol acetate rats with peripubertal diazepam showed significantly more parvalbumin interneurons (3355±173 in the ventral subiculum, 1211±76 in the dentate gyrus) than methylazoxymethanol acetate without diazepam (2375±109 and 824±54, respectively). No change was found in the basolateral amygdala.

Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Du, Yijuan
Grace, Anthony
Date: 18 July 2016
Date Type: Publication
Journal or Publication Title: International Journal of Neuropsychopharmacology
Volume: 19
Number: 11
Publisher: Oxford University Press
Page Range: pyw065
DOI or Unique Handle: 10.1093/ijnp/pyw065
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Refereed: No
ISSN: 1461-1457
Official URL:
Article Type: Research Article
Date Deposited: 13 May 2020 16:39
Last Modified: 13 May 2020 16:39


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