Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

“Loser” or “Popular”?: Neural response to social status words in adolescents with major depressive disorder

Silk, Jennifer S. and Lee, Kyung Hwa and Kerestes, Rebecca and Griffith, Julianne M. and Dahl, Ronald E. and Ladouceur, Cecile D. (2017) “Loser” or “Popular”?: Neural response to social status words in adolescents with major depressive disorder. Developmental Cognitive Neuroscience, 28. pp. 1-11. ISSN 18789293

Published Version

Download (2MB) | Preview


Concerns about social status are ubiquitous during adolescence, with information about social status often conveyed in text formats. Depressed adolescents may show alterations in the functioning of neural systems supporting processing of social status information. We examined whether depressed youth exhibited altered neural activation to social status words in temporal and prefrontal cortical regions thought to be involved in social cognitive processing, and whether this response was associated with development. Forty-nine adolescents (ages 10–18; 35 female), including 20 with major depressive disorder and 29 controls, were scanned while identifying the valence of words that connoted positive and negative social status. Results indicated that depressed youth showed reduced late activation to social status (vs neutral) words in the superior temporal cortex (STC) and medial prefrontal cortex (MPFC); whereas healthy youth did not show any significant differences between word types. Depressed youth also showed reduced late activation in the dorsolateral prefrontal cortex and fusiform gyrus to negative (vs positive) social status words; whereas healthy youth showed the opposite pattern. Finally, age was positively associated with MPFC activation to social status words. Findings suggest that hypoactivation in the “social cognitive brain network” might be implicated in altered interpersonal functioning in adolescent depression.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Silk, Jennifer
Lee, Kyung Hwa
Kerestes, Rebecca
Griffith, Julianne M.
Dahl, Ronald E.
Ladouceur, Cecile
Date: 23 September 2017
Date Type: Publication
Journal or Publication Title: Developmental Cognitive Neuroscience
Volume: 28
Publisher: Elsevier
Page Range: pp. 1-11
DOI or Unique Handle: 10.1016/j.dcn.2017.09.005
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
ISSN: 18789293
Official URL:
Article Type: Research Article
Date Deposited: 13 May 2020 15:28
Last Modified: 13 May 2020 15:28


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item