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Preparation, Properties and Applications of Sequence-Controlled Polymers

Swisher, Jordan H (2020) Preparation, Properties and Applications of Sequence-Controlled Polymers. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Synthetic sequence-controlled polymers (SCPs) are an emerging category of polymeric materials and the work presented in the projects described in this thesis advance our understanding of these materials in four areas: (I) preparation, (II) structure-function relationships, (III) potential applications, and (IV) the fundamental definition of SCPs. In the first project, an investigation into how standard synthetic methods used to make SCPs can impact the resulting properties in sequence-controlled polyesters is described. This project directly addresses areas I and II, looking at various synthetic techniques and the inherent properties imparted by those techniques, in which we were able to correlate structural characteristics (flexibility, hydrophobicity, etc.) with properties such as hardness and hydrolytic stability. Next, oligoester peptide mimics were prepared and conjugated to polyethylene glycol (PEG) in an effort to capture the functionality of a peptide-PEG conjugate as a drug delivery agent in a sequence-controlled polyester, addressing items II and III. We found that the polyester-PEG conjugates outperformed the peptide-PEG template in both drug encapsulation and delivery, and also found that monomer sequence impacted performance. The third project involved the synthesis of a synthetically challenging monomer, S-methyl glycolide, followed by a collaboration to optimize the sequence-controlled polymerization of this monomer. The synthesis and study of this polymer also advances areas I and II. Finally, a novel synthetic method was developed for the synthesis of sequence-controlled multiblock copolymers using self-templating pre-assembly. The work on this project presented below addresses item I and IV, the former due to the novel synthetic aspect and the latter due to the expansion of the current definition of a sequence-controlled polymer. This project moves beyond monomer-by-monomer sequence to a longer-range block-by-block sequence. Additionally, this last work leaves open the possibility of addressing items II and III in this new realm of sequence-controlled polymers.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Swisher, Jordan Hjhs47@pitt.edujhs470000-0002-4999-9359
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMeyer, Tara Ytmeyer@pitt.edu
Committee MemberLaaser, Jenniferj.laaser@pitt.edu
Committee MemberHorne, Sethhorne@pitt.edu
Committee MemberNoonan, Kevinnoonan@andrew.cmu.edu
Date: 8 June 2020
Date Type: Publication
Defense Date: 24 January 2020
Approval Date: 8 June 2020
Submission Date: 25 March 2020
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 355
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Polymer Sequence-control Polymer synthesis
Date Deposited: 08 Jun 2020 17:04
Last Modified: 08 Jun 2020 17:04
URI: http://d-scholarship.pitt.edu/id/eprint/38970

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