Thompson, JS and Porter, KA and Hayashida, N and Mcnamara, DJ and Parker, TS and Russell, WJI and Francavilla, A and Starzl, TE
(1983)
Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass: Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy.
Hepatology, 3 (4).
581 - 587.
ISSN 0270-9139
Abstract
External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found. Thus, the experiments did not confirm recent observations by others in rats that BF prevents or reverses the hepatic injury of PCS. As estimated by plasma mevalonic acid determinations, the increase in hepatic cholesterol synthesis that is characteristic after BF or IB was suppressed in animals with PCS. BF and IB reduced but did not eliminate the postprandial elevation in serum bile acid that occurs after PCS. The findings have possible relevance in planning the treatment of patients with familial hypercholesterolemia with the combined use of PCS and IB. Copyright © 1983 American Association for the Study of Liver Diseases
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Thompson, JS | | | | | Porter, KA | | | | | Hayashida, N | | | | | Mcnamara, DJ | | | | | Parker, TS | | | | | Russell, WJI | | | | | Francavilla, A | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1983 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Hepatology |
| Volume: |
3 |
| Number: |
4 |
| Page Range: |
581 - 587 |
| DOI or Unique Handle: |
10.1002/hep.1840030418 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0270-9139 |
| Other ID: |
uls-drl:31735062114800, Starzl CV No. 512 |
| Date Deposited: |
08 Apr 2010 17:08 |
| Last Modified: |
29 Jan 2019 15:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3898 |
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