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Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

Ottilie, Sabine and Goldgof, Gregory M. and Cheung, Andrea L. and Walker, Jennifer L. and Vigil, Edgar and Allen, Kenneth E. and Antonova-Koch, Yevgeniya and Slayman, Carolyn W. and Suzuki, Yo and Durrant, Jacob D. (2018) Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. Journal of Cheminformatics, 10 (1). ISSN 1758-2946

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Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatments. We identify NSC11668 and hitachimycin as structurally distinct antifungals that inhibit yeast ScPma1p. These compounds provide new opportunities for drug discovery aimed at this important target.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ottilie, Sabine
Goldgof, Gregory M.
Cheung, Andrea L.
Walker, Jennifer
Vigil, Edgar
Allen, Kenneth E.
Antonova-Koch, Yevgeniya
Slayman, Carolyn W.
Suzuki, Yo
Durrant, Jacob
Date: 2018
Date Type: Publication
Journal or Publication Title: Journal of Cheminformatics
Volume: 10
Number: 1
Publisher: BMC
DOI or Unique Handle: 10.1186/s13321-018-0261-3
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
Uncontrolled Keywords: antifungal, PMA1, P-type ATPase, computer modeling, saccharomyces cerevisiae, in vitro evolution, drug resistance
ISSN: 1758-2946
Official URL:
Funders: Bill and Melinda Gates Founda‑ tion, Grand Challenge in Global Health Exploration Grant, UC San Diego Medical Scientist Training Program, DoD National Defense Science and Engineering Fellowship Program, National Institutes of Health
Article Type: Research Article
Date Deposited: 13 May 2020 14:59
Last Modified: 13 May 2020 14:59


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