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Maternal Hypertension after a Low-Birth-Weight Delivery Differs by Race/Ethnicity: Evidence from the National Health and Nutrition Examination Survey (NHANES) 1999–2006

Guo, Yiru and Xu, Jia and Barinas-Mitchell, Emma and Kuller, Lewis H. and Youk, Ada O. and Catov, Janet M. (2014) Maternal Hypertension after a Low-Birth-Weight Delivery Differs by Race/Ethnicity: Evidence from the National Health and Nutrition Examination Survey (NHANES) 1999–2006. PLoS ONE, 9 (8). e104149. ISSN 1932-6203

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Studies have suggested an increase in maternal morbidity and mortality due to cardiovascular diseases in women with a prior low-birth-weight (LBW, <2,500 grams) delivery. This study evaluated blood pressure and hypertension in women who reported a prior preterm or small-for-gestational-age (SGA) LBW delivery in the National Health and Nutrition Examination Survey 1999–2006 (n = 6,307). This study also aimed to explore if race/ethnicity, menopause status, and years since last pregnancy modified the above associations. A total of 3,239 white, 1,350 black, and 1,718 Hispanics were assessed. Linear regression models were used to evaluate blood pressure by birth characteristics (preterm-LBW, SGA-LBW, and birthweight ≥2,500). Logistic regression models estimated the odds ratios (OR) of hypertension among women who reported a preterm-LBW or SGA-LBW delivery compared with women who reported an infant with birthweight ≥2,500 at delivery. Overall, there was a positive association between a preterm-LBW delivery and hypertension (adjusted OR = 1.39, 95% confidence interval (CI) 1.02–1.90). Prior SGA-LBW also increased the odds of hypertension, but the estimate did not reach statistical significance (adjusted OR = 1.21, 95% CI 0.76–1.92). Race/ethnicity modified the above associations. Only black women had increased risk of hypertension following SGA-LBW delivery (adjusted OR = 2.09, 95% CI 1.12–3.90). Black women were at marginally increased risk of hypertension after delivery of a preterm-LBW (adjusted OR = 1.49, 95% CI 0.93–2.38). Whites and Hispanics had increased, but not statistically significant, risk of hypertension after a preterm-LBW (whites: adjusted OR = 1.39, 95% CI 0.92–2.10; Hispanics: adjusted OR = 1.22, 95% CI 0.62–2.38). Stratified analysis indicated that the associations were stronger among women who were premenopausal and whose last pregnancy were more recent. The current study suggests that in a representative United States population, women with a history of preterm- or SGA-LBW deliveries have increased odds of hypertension and this risk appears to be higher for black women and younger women.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Guo, Yiru
Xu, Jia
Barinas-Mitchell, Emma
Kuller, Lewis
Youk, Ada
Catov, Janet
Centers: Other Centers, Institutes, Offices, or Units > Center for Public Health Practice
Date: 5 August 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 8
Publisher: Public Library of Science (PLoS)
Page Range: e104149
DOI or Unique Handle: 10.1371/journal.pone.0104149
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1932-6203
Official URL:
Article Type: Research Article
Date Deposited: 19 Jun 2020 13:43
Last Modified: 19 Jun 2020 13:43


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