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Investigating Genetic Interactions Between Two Key Meiotic Genes xnd-1 and him-17, in C. elegans

Chen, Lingling (2020) Investigating Genetic Interactions Between Two Key Meiotic Genes xnd-1 and him-17, in C. elegans. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Meiotic chromosomes segregation errors in the oocyte are the principal risk factor in miscarriage, congenital birth defects and age-related fertility decrease. Aneuploidy from meiotic chromosomes segregation is a major underlying cause for human chromosomal abnormalities. Previous studies identified several key DNA recombination genes in meiosis and mitosis in both human and other species, including but not limited to SPO-11, MRE-11, RAD-50 etc. Mutations in these genes associate with cancers in human. Although mutations or variations of some meiotic genes in species, such as Saccharomyces cerevisiae, Drosophila melanogaster and Caenorhabditis elegans, are discovered to function in DNA recombination, no specific genes were studied in human meiotic nondisjunction.
Public Health Significance: Miscarriages, infertility and trisomy pregnancies are among the most common public health issues around the world. The goal of this research is to understand potential mechanism of meiotic chromosomal nondisjunction with C. elegans model. This research shows that HIM-17 and XND-1 interact in the same pathway when double-strand breaks (DSBs) are formed. Further studies should investigate how HIM-17 and XND-1regulate HIM-5 in this pathway and other pathways in regulating HIM-5


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chen, Linglingchenlingling1002@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairYanotiwz, Judithyanowitzjl@mwri.magee.edu
Committee MemberPadiath, Quasar Saleemqpadiath@pitt.edu
Committee MemberFeingold, Eleanorfeingold@pitt.edu
Date: 30 July 2020
Date Type: Publication
Defense Date: 16 April 2020
Approval Date: 30 July 2020
Submission Date: 15 May 2020
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 55
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Human Genetics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: meiosis, c.elegans,xnd-1,him-17, nondisjunction
Date Deposited: 30 Jul 2020 18:04
Last Modified: 30 Jul 2020 18:04
URI: http://d-scholarship.pitt.edu/id/eprint/39043

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