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Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Kerestes, Rebecca and Phal, Pramit M. and Steward, Chris and Moffat, Bradford A. and Salinas, Simon and Cox, Kay L. and Ellis, Kathryn A. and Cyarto, Elizabeth V. and Ames, David and Martins, Ralph N. and Masters, Colin L. and Rowe, Christopher C. and Sharman, Matthew J. and Salvado, Olivier and Szoeke, Cassandra and Lai, Michelle and Lautenschlager, Nicola T. and Desmond, Patricia M. (2018) Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease. BJPsych Open, 1 (2). pp. 139-148. ISSN 2056-4724

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Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.
To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.
Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.
ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.
The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Phal, Pramit M.
Steward, Chris
Moffat, Bradford A.
Salinas, Simon
Cox, Kay L.
Ellis, Kathryn A.
Cyarto, Elizabeth V.
Ames, David
Martins, Ralph N.
Masters, Colin L.
Rowe, Christopher C.
Sharman, Matthew J.
Salvado, Olivier
Szoeke, Cassandra
Lai, Michelle
Lautenschlager, Nicola T.
Desmond, Patricia M.
Date: 2 January 2018
Date Type: Publication
Journal or Publication Title: BJPsych Open
Volume: 1
Number: 2
Publisher: Cambridge University Press
Page Range: pp. 139-148
DOI or Unique Handle: 10.1192/bjpo.bp.115.001339
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
ISSN: 2056-4724
Official URL:
Article Type: Research Article
Date Deposited: 19 Jun 2020 13:20
Last Modified: 19 Jun 2020 13:20


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