Kerestes, Rebecca and Phal, Pramit M. and Steward, Chris and Moffat, Bradford A. and Salinas, Simon and Cox, Kay L. and Ellis, Kathryn A. and Cyarto, Elizabeth V. and Ames, David and Martins, Ralph N. and Masters, Colin L. and Rowe, Christopher C. and Sharman, Matthew J. and Salvado, Olivier and Szoeke, Cassandra and Lai, Michelle and Lautenschlager, Nicola T. and Desmond, Patricia M.
(2018)
Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease.
BJPsych Open, 1 (2).
pp. 139-148.
ISSN 2056-4724
Abstract
Background
Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.
Aims
To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.
Method
Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.
Results
ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.
Conclusions
The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Kerestes, Rebecca | kerestesrv@upmc.edu | | | | Phal, Pramit M. | | | | | Steward, Chris | | | | | Moffat, Bradford A. | | | | | Salinas, Simon | | | | | Cox, Kay L. | | | | | Ellis, Kathryn A. | | | | | Cyarto, Elizabeth V. | | | | | Ames, David | | | | | Martins, Ralph N. | | | | | Masters, Colin L. | | | | | Rowe, Christopher C. | | | | | Sharman, Matthew J. | | | | | Salvado, Olivier | | | | | Szoeke, Cassandra | | | | | Lai, Michelle | | | | | Lautenschlager, Nicola T. | | | | | Desmond, Patricia M. | | | |
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| Date: |
2 January 2018 |
| Date Type: |
Publication |
| Journal or Publication Title: |
BJPsych Open |
| Volume: |
1 |
| Number: |
2 |
| Publisher: |
Cambridge University Press |
| Page Range: |
pp. 139-148 |
| DOI or Unique Handle: |
10.1192/bjpo.bp.115.001339 |
| Schools and Programs: |
School of Medicine > Psychiatry |
| Refereed: |
Yes |
| ISSN: |
2056-4724 |
| Official URL: |
http://dx.doi.org/10.1192/bjpo.bp.115.001339 |
| Article Type: |
Research Article |
| Date Deposited: |
19 Jun 2020 13:20 |
| Last Modified: |
19 Jun 2020 13:20 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/39067 |
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